What is 5-HTP?

5-HTP (5-hydroxytryptophan) is an amino acid that plays an important role in the production of serotonin, a neurotransmitter known to be associated with the feeling of well-being. In addition to supporting a healthy mental outlook and mood, studies have also shown serotonin to encourage deeper sleep and to support healthy appetite regulation. Unlike oral serotonin, 5-HTP is able to effectively cross the blood-brain barrier and increase synthesis of serotonin in the central nervous system. 5-HTP is extracted naturally from the seed of the African plant Griffonia simplicifolia.


Stressful lifestyles and poor diets often cause a depletion of serotonin levels. 5-HTP has been used for many years to replenish serotonin levels and support a healthy mood and sleep cycle regulation. Supplementation with 5-HTP has been shown to increase serotonin levels in the central nervous system. The essential amino acid, tryptophan is converted into 5-HTP by the enzyme tryptophan hydroxylase. Tryptophan hydroxylase can be inhibited by a number of factors including stress, insulin resistance, pyridoxine (vitamin B6) deficiency and insufficient magnesium levels. Supplementation with 5-HTP bypasses the conversion of tryptophan to 5-HTP and thus supports optimal levels of serotonin. [1,2] 5-HTP also readily crosses the blood-brain barrier (BBB) and bypasses competition with other amino acids, making it a more efficient precursor for serotonin production. [1-3]

Mood and Comfort†

Adequate levels of serotonin are associated with a sense of calmness and relaxation. [1-4] Several studies have demonstrated that 5-HTP supports a healthy frame of mind, good energy levels, comfortable movement and restful sleep. [1,5,6,7] Published studies of doses between 100-600 mg/day have also shown 5-HTP to support occasional headaches. [ 8-10]

Sleep Support†

Clinical studies have shown 5-HTP helps to maintain healthy sleep cycle regulation. 5-HTP improves quality of sleep by extending the rapid eye movement (REM) phase as well as increasing the deep sleep stages of non-REM sleep without increasing total sleep time. In addition, 5-HTP promotes the release of melatonin by the pineal gland inside the brain and increases the length of REM.
[3,11] In children, supplementation with 5-HTP may help support peaceful sleep [12] and decrease the incidence of night terrors. [13] 5-HTP has also been found to raise plasma cortisol levels, causing a transient increase in growth hormone (at 150 mg dose) and, in men only, to support healthy levels of thyroid stimulating hormone. [14,15]

Appetite Regulation†

5-HTP has been found to assist with carbohydrate cravings. 5-HTP is known to support normal hypothalamic regulation, which includes appetite homeostasis. [16] In one study, sublingual 5-HTP administered 5 times per day for 8 weeks in adult overweight women significantly supported feelings of post-meal hunger satisfaction. [17] An additional double-blind study using 900 mg daily of 5-HTP was found to produce significant weight loss in obese women. Reduced carbohydrate intake and improved satiety was observed following 5-HTP administration. [18]

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